current concepts on anti-phospholipase a2 receptor antibody in idiopathic membranous nephropathy.

Current concepts on anti-Phospholipase A2 receptor antibody in Idiopathic membranous nephropathy

Implication for health policy/practice/research/medical education: Phospholipase A2 receptor, is normally expressed in podocyte membrane. In fact the phospholipase A2 receptor (PLA2R) is a type I transmembrane glycoprotein related to the C-type animal lectin family such as the mannose receptor. PLA2R regulates a number of biological responses produced by secretory phospholipase A2s (sPLA2s). De...

Anti-phospholipase A2 receptor antibody in idiopathic membranous nephropathy: New concepts

transmembrane glycoprotein related to the C‐type animal lectin family like the mannose receptor. More recent observations, revealed that antibodies to the PLA2r are IgG4.[24,31,32] These IgG4 antibodies can be identified in the glomerular immune complexes and they co‐localize with PLA2r. Moreover, in secondary forms of membranous nephropathy, such IgG4 antibodies are lacking or less prevalent.[...

Anti-phospholipase A2 receptor antibody in membranous nephropathy.

The M-type phospholipase A2 receptor (PLA2R) is a target autoantigen in adult idiopathic membranous nephropathy (MN), but the prevalence of autoantibodies against PLA2R is unknown among Chinese patients with MN. Here, we measured anti-PLA2R antibody in the serum of 60 patients with idiopathic MN, 20 with lupus-associated MN, 16 with hepatitis B (HBV)-associated MN, and 10 with tumor-associated ...

Idiopathic membranous nephropathy and anti-phospholipase A2 receptor antibodies.

Anti-phospholipase A2 receptor antibody in idiopathic membranous nephropathy: A report from Iranian population.

BACKGROUND Idiopathic Membranous Nephropathy (iMN) is the most common cause of nephrotic syndrome in adults. Approximately one third of patients with iMN progress to end-stage renal disease. Anti-phospholipase A2-receptor (anti-PLA2R) antibodies are present in patients with iMN and appear to play a role in the pathogenesis of iMN. OBJECTIVES In this study, we explored the prevalence of anti-P...

Anti-phospholipase A2 receptor antibody levels at diagnosis predicts spontaneous remission of idiopathic membranous nephropathy

Background: The diagnostic role of circulating anti-phospholipase A2 receptor antibodies (anti-PLA2R Abs) is now well recognized in idiopathic membranous nephropathy (iMN). These Abs could also be interesting as predictors of clinical outcome. In this study, we explored the prognostic value of anti-PLA2R Abs measured in a cohort of iMN patients, with a special focus on their ability to detect p...